Mechanical strain exacerbates Pseudomonas infection in an organoid-based pneumonia-on-a-chip model

J Clin Invest. 2025 Nov 18;136(2):e192454. doi: 10.1172/JCI192454. eCollection 2026 Jan 16.

Abstract

Using an advanced human lung-on-a-chip model, this study shows that increased mechanical strain can make the lungs more vulnerable to harmful bacteria such as Pseudomonas aeruginosa.

Keywords: Adult stem cells; Bacterial infections; Infectious disease; Pulmonology.

MeSH terms

  • Humans
  • Lab-On-A-Chip Devices*
  • Lung* / microbiology
  • Lung* / pathology
  • Models, Biological*
  • Organoids* / microbiology
  • Organoids* / pathology
  • Pneumonia* / microbiology
  • Pneumonia* / pathology
  • Pneumonia, Bacterial* / microbiology
  • Pneumonia, Bacterial* / pathology
  • Pseudomonas Infections* / metabolism
  • Pseudomonas Infections* / microbiology
  • Pseudomonas Infections* / pathology
  • Pseudomonas aeruginosa*
  • Stress, Mechanical*