Genetic screening identifies Ube2v1 as a suppressor of immunoglobulin class switch recombination in CH12F3 cells

Mol Biol Rep. 2025 Nov 19;53(1):101. doi: 10.1007/s11033-025-11268-7.

Xu Wang¹, Cuicui Xia^{2

3}, Xiaofei Zhang⁴

¹ Guangzhou National Laboratory, Guangzhou, Guangdong, 510005, China. wang_xu2@gzlab.ac.cn.
² Center for Cell Lineage Altas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, Guangdong, China.
³ Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230026, China.
⁴ Center for Cell Lineage Altas, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong-Hong Kong Joint Laboratory for Stem Cell and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, Guangdong, China. zhang_xiaofei@gibh.ac.cn.

No abstract available

Keywords: Antibody class switch; Germline transcription; Ube2v1; Ubiquitination.

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