Lendenfeldaranes W-Y, new 24-homoscalaranes from a marine sponge Lendenfeldia species

Chih-Yin Huang; Bo-Rong Peng; Yueh-Wen Liu; You-Ying Chen; Jui-Hsin Su; Chia-Ching Liaw; Jih-Jung Chen; Chung-Chih Tseng; Yu-Jen Wu; Yuan-Bin Cheng; Lun Kelvin Tsou; Mingzi M Zhang; Zhi-Hong Wen; Li-Guo Zheng; Ping-Jyun Sung

doi:10.1039/d5ra07083j

Lendenfeldaranes W-Y, new 24-homoscalaranes from a marine sponge Lendenfeldia species

RSC Adv. 2025 Nov 18;15(52):44877-44882. doi: 10.1039/d5ra07083j. eCollection 2025 Nov 11.

Authors

Chih-Yin Huang^{1

2}, Bo-Rong Peng³, Yueh-Wen Liu⁴, You-Ying Chen⁵, Jui-Hsin Su^{5

6

7}, Chia-Ching Liaw^{8

9

10

11

12}, Jih-Jung Chen¹⁰, Chung-Chih Tseng^{2

13}, Yu-Jen Wu¹⁴, Yuan-Bin Cheng⁷, Lun Kelvin Tsou¹⁵, Mingzi M Zhang¹⁶, Zhi-Hong Wen^{5

7}, Li-Guo Zheng^{5

17}, Ping-Jyun Sung^{5

7

9

18

19

20

21}

Affiliations

¹ Department of Orthopedics, Kaohsiung Armed Forces General Hospital Kaohsiung 802301 Taiwan.
² Institute of Medical Science and Technology, National Sun Yat-sen University Kaohsiung 804201 Taiwan.
³ Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology Taoyuan 333324 Taiwan.
⁴ Department of Cosmetics and Fashion Styling, Chien Shiu University Kaohsiung 833301 Taiwan.
⁵ National Museum of Marine Biology and Aquarium Pingtung 944401 Taiwan t0919928409@gmail.com pjsung@nmmba.gov.tw.
⁶ Graduate Institute of Marine Biology, National Dong Hwa University Pingtung 944401 Taiwan.
⁷ Department of Marine Biotechnology and Resources, National Sun Yat-sen University Kaohsiung 804201 Taiwan.
⁸ National Research Institute of Chinese Medicine, MOHW Taipei 112304 Taiwan.
⁹ Graduate Institute of Natural Products, Kaohsiung Medical University Kaohsiung 807378 Taiwan.
¹⁰ Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chian Tung University Taipei 112304 Taiwan.
¹¹ Department of Biochemical Science and Technology, National Chiayi University, Chiayi University Chiayi 600048 Taiwan.
¹² School of Chinese Medicine, National Yang Ming Chian Tung University Taipei 112304 Taiwan.
¹³ School of Dentistry, College of Oral Medicine, National Defence Medical University Taipei 114201 Taiwan.
¹⁴ Yu Jun Biotechnology Co., Ltd Donggang Pingtung 928003 Taiwan.
¹⁵ Institute of Biotechnology and Pharmaceutical Research, National Health Research Institute Miaoli 350401 Taiwan.
¹⁶ Institute of Molecular and Genomics Medicine, National Health Research Institute Miaoli 350401 Taiwan.
¹⁷ Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University Kaohsiung 804201 Taiwan.
¹⁸ Chinese Medicine Research and Development Center, China Medical University Hospital Taichung 404394 Taiwan.
¹⁹ Program in Pharmaceutical Biotechnology, Fu Jen Catholic University New Taipei City 242062 Taiwan.
²⁰ Department of Biochemistry and Molecular Medicine, National Dong Hwa University Hualien 974301 Taiwan.
²¹ School of Medicine, Kaohsiung Medical University Kaohsiung 807378 Taiwan.

Abstract

Three new scalarane-type sesterterpenoids, lendenfeldaranes W-Y (1-3), along with a known analogue, lendenfeldarane D (4), were isolated from a marine sponge identified as Lendenfeldia species. The structures of all isolates were determined based on spectroscopic methods. Scalarane 1 exhibited significant activity in enhancing alkaline phosphatase (ALP) activity.