Aim: The aim of the study is to evaluate the distribution and drug resistance of infectious pathogens in hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD).
Methods: This is a retrospective study of AECOPD patients who underwent pathogen evaluation and drug susceptibility tests.
Results: A total of 199 hospitalized AECOPD patients were analyzed. Among them, 77.9% had monoinfection, and 22.1% had multiple infections. Two hundred and eighty-eight strains were isolated, with 61.1% gram-negative, 3.8% gram-positive, and 35.0% fungi, while 58 strains were colonized. Common bacteria included Haemophilus parainfluenzae, Acinetobacter baumannii, and Pseudomonas aeruginosa. Staphylococcus aureus and Enterococcus faecalis were the main gram-positive cocci, and Pseudohyphae were the main fungi. Fifty gram-negative strains showed drug resistance (19 colonized strains), with high resistance to ceftriaxone in A. baumannii, P. aeruginosa, Klebsiella pneumoniae, and Escherichia coli. Methicillin-resistant S. aureus was resistant to penicillin but sensitive to other antibiotics.
Conclusion: The study highlights the distribution of pathogens and the prevalence of drug-resistant strains among AECOPD patients.
Keywords: acute exacerbation; chronic obstructive pulmonary disease; drug susceptibility; hospitalization; pathogenic bacteria.
Copyright © 2025 Songsong Yu and Tiecheng Yang. Pulmonary Medicine published by John Wiley & Sons Ltd.