An Atypical Case of Exophiala Bergeri Chromoblastomycosis in an Immunosuppromised Individual

Clin Med Res. 2025 Nov;23(3):125-128. doi: 10.3121/cmr.2025.2044.

Abstract

Chromoblastomycosis (CBM) is a rare chronic, granulomatous mycosis affecting the skin and subcutaneous tissue. It is a deep, slow growing, fungal infection that most often presents with epidermal changes that clinically appear as a hypertrophic and verrucous plaque. We describe an atypical presentation of an immunocompromised male patient, age 76 years, who presented with a 4-month history of painless subcutaneous firm nodules of the left fifth finger. The fungal culture grew Exophiala bergeri, and histopathology showed medlar bodies with lack of pseuodepitheliomatous hyperplasia or epidermal changes commonly seen in CBM. To our knowledge, this is the first case of Exophiala bergeri CBM in the United States, highlighting its unique clinical presentation and expanding the differentials for a subcutaneous nodule.

Keywords: Antifungal therapy; Chromoblastomycosis; Exophiala Bergeri; Neglected fungal infection; Traumatic inoculation; Tropical environment; sclerotic bodies.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chromoblastomycosis* / diagnosis
  • Chromoblastomycosis* / drug therapy
  • Chromoblastomycosis* / immunology
  • Chromoblastomycosis* / microbiology
  • Chromoblastomycosis* / pathology
  • Exophiala* / isolation & purification
  • Humans
  • Immunocompromised Host*
  • Male