Impairment of hepatic uptake of rifamycin antibiotics by probenecid, and its therapeutic implications

Lancet. 1973 Dec 22;2(7843):1401-5. doi: 10.1016/s0140-6736(73)92799-2.
No abstract available

Publication types

  • Comparative Study

MeSH terms

  • Administration, Oral
  • Animals
  • Bilirubin / blood
  • Bilirubin / metabolism
  • Costs and Cost Analysis
  • Drug Synergism
  • Drug Therapy, Combination
  • Health Expenditures
  • Humans
  • In Vitro Techniques
  • Liver / metabolism*
  • Liver / physiopathology
  • Liver Function Tests
  • Male
  • Probenecid / administration & dosage
  • Probenecid / metabolism
  • Probenecid / pharmacology*
  • Rats
  • Rifamycins / administration & dosage
  • Rifamycins / blood
  • Rifamycins / metabolism*
  • Sulfobromophthalein
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / metabolism
  • Tuberculosis, Pulmonary / physiopathology

Substances

  • Rifamycins
  • Sulfobromophthalein
  • Probenecid
  • Bilirubin