Towards insulin independence in type 1 diabetes: Prospects for prevention and cure

PLoS Med. 2025 Nov 25;22(11):e1004813. doi: 10.1371/journal.pmed.1004813. eCollection 2025 Nov.

Abstract

The discovery of insulin transformed type 1 diabetes from an acutely lethal illness to a chronic disease that is managed with insulin dependence. Now, exciting developments in preventive treatments and stem cell-based therapies bring the prospects of arresting the disease and achieving insulin independence for type 1 diabetics closer to reality.

MeSH terms

  • Animals
  • Diabetes Mellitus, Type 1* / drug therapy
  • Diabetes Mellitus, Type 1* / prevention & control
  • Diabetes Mellitus, Type 1* / therapy
  • Humans
  • Hypoglycemic Agents / therapeutic use
  • Insulin* / metabolism
  • Insulin* / therapeutic use
  • Stem Cell Transplantation

Substances

  • Hypoglycemic Agents
  • Insulin