Induction of cuproptosis enhances sensitivity and overcomes resistance to osimertinib in lung cancer

Signal Transduct Target Ther. 2025 Nov 26;10(1):390. doi: 10.1038/s41392-025-02480-9.

Yi-Bo Gao^#^{1

2}, Jia-Ming Xie^#³, Yan-Nan Yang^#⁴, Xiao-Xiang Zhou^#³, Jie He⁵

¹ Central Laboratory & Shenzhen Key Laboratory of Epigenetics and Precision Medicine for Cancers, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China. gaoyibo@cicams.ac.cn.
² Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. gaoyibo@cicams.ac.cn.
³ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
⁴ Central Laboratory & Shenzhen Key Laboratory of Epigenetics and Precision Medicine for Cancers, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.
⁵ Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. hejie@cicams.ac.cn.

^# Contributed equally.

No abstract available

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