Background: Many diseases mimic tumors radiographically and clinically.
Case report: Here we are presenting a challenging case. A 71-year-old patient who presented with chronic back pain was scheduled to have a sacroiliac joint injection. In the weeks before his injection, he developed isolated right-hand weakness and was confirmed to have a resolving hematoma that caused cortical hand syndrome, confirmed by pathology after surgery, and mimicked a tumor radiographically and clinically.
Conclusion: In conclusion, it is very important to keep a broad differential when encountering challenging cases.
Keywords: Case report; hematoma; sacroiliac joint injection; tumor.