PatientEase-Domain-Aware RAG for Rehabilitation Instruction Simplification

Bioengineering (Basel). 2025 Nov 3;12(11):1204. doi: 10.3390/bioengineering12111204.

Abstract

Background: Rehabilitation depends on using instructional materials, which many patients find difficult to understand; thus, their adherence to the safety and care may be affected. Text simplification systems used, in general, do not usually focus on procedure-oriented guidance or the degree of personalization required in rehabilitation settings.

Methods: We present PatientEase, a domain-aware retrieval-augmented generation framework that changes rehabilitation instructions to simple words without changing the clinical meaning. PatientEase incorporates two complementary retrievers that is a corpus retriever that is tuned for rehabilitation and a user-aligned retriever that is conditioned on patient profiles, together with a role-structured, multi-agent rewriting pipeline; outputs can be further refined by using reinforcement learning from human feedback with a composite reward for readability, factuality, and clinician-preferred structure.

Results: The latter was quite comprehensively compared in four benchmark tests against baselines, wherein SARI, FKGL, BERTScore, and MedEntail indices are employed, as well as clinician-patient assessments. PatientEase achieves 52.7 SARI and 92.1% factual entailment, and receives the highest fluency and simplicity ratings; ablations also underline each module's role.

Conclusions: PatientEase paves the road for safer, patient-centered communication in rehabilitation and lays the groundwork for trustworthy clinical dialogue systems.

Keywords: clinical natural language processing (NLP); domain adaptation; medical text simplification; multi-agent coordination; patient-centered healthcare communication; rehabilitation informatics; reinforcement learning from human feedback (RLHF); retrieval-augmented generation (RAG).