Endocrine-disrupting chemicals in cosmetics: mechanistic insights and their impact on human and skin health

Rev Endocr Metab Disord. 2026 Feb;27(1):123-138. doi: 10.1007/s11154-025-10006-5. Epub 2025 Nov 27.

Abstract

The increasing use of cosmetics and therapeutic products has raised concerns about their effects on skin health and overall well-being. This review focuses on the toxicological impact of cosmetic ingredients, particularly endocrine-disrupting chemicals (EDCs) such as benzophenones, triclosan, phthalates, and parabens. Frequently present in skincare, haircare, and cosmetic products, these compounds have been associated with adverse outcomes, including carcinogenesis, skin disorders, hormonal imbalances, and reproductive health issues. Despite extensive research on parabens, phthalates, triclosan, and benzophenones, significant uncertainties persist, underscoring the need for further investigation to understand previous findings better. To mitigate these risks, the review recommends adopting safer alternatives, increasing consumer awareness, and enforcing stricter regulatory measures. This comprehensive analysis aims to bridge existing knowledge gaps, empower consumers to make informed choices, and advocate for strict safety standards in personal care products to safeguard skin health and support long-term well-being.

Keywords: Benzophenones; Cosmetic ingredients; Parabens; Phthalates; Skincare; Triclosan.

Publication types

  • Review

MeSH terms

  • Animals
  • Cosmetics* / adverse effects
  • Cosmetics* / chemistry
  • Endocrine Disruptors* / adverse effects
  • Endocrine Disruptors* / toxicity
  • Humans
  • Phthalic Acids / adverse effects
  • Skin Diseases* / chemically induced
  • Skin* / drug effects

Substances

  • Cosmetics
  • Endocrine Disruptors
  • Phthalic Acids