High-Resolution 3-Dimensional MRI of the Oculomotor Nerve: Anatomic and Pathologic Considerations by Segment

J Neuroophthalmol. 2025 Dec 1;45(4):402-412. doi: 10.1097/WNO.0000000000002412.

Abstract

Background: CN III is a pure motor cranial nerve that innervates the majority of the extraocular muscles. CN III palsy is the most common cranial nerve palsy with an incidence of 3-4 cases per 100,000.

Evidence acquisition: High-resolution, 3-dimensional, skull base MRI allows for high spatial resolution and high signal-to-noise ratio allowing for optimal evaluation of CN III pathology by segment.

Results: A systemic approach is used to describe the segmental anatomy of CN III, its vascular supply, clinical pathologic manifestations, and imaging correlate.

Conclusions: We present a segmental approach to high-resolution 3-dimensional MRI of the oculomotor nerve from nuclear to extraforaminal segments.

Publication types

  • Review

MeSH terms

  • Humans
  • Imaging, Three-Dimensional* / methods
  • Magnetic Resonance Imaging* / methods
  • Oculomotor Muscles / innervation
  • Oculomotor Nerve Diseases* / diagnosis
  • Oculomotor Nerve Diseases* / pathology
  • Oculomotor Nerve* / anatomy & histology
  • Oculomotor Nerve* / diagnostic imaging
  • Oculomotor Nerve* / pathology