Unlocking human brain networks by assembling circuits in vitro and in vivo

Wei Pang; Yangfei Xiang

doi:10.1016/j.stem.2025.10.011

Unlocking human brain networks by assembling circuits in vitro and in vivo

Cell Stem Cell. 2025 Dec 4;32(12):1795-1797. doi: 10.1016/j.stem.2025.10.011.

Authors

Wei Pang¹, Yangfei Xiang²

Affiliations

¹ School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
² School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China; Shanghai Clinical Research and Trial Center, Shanghai 201210, China. Electronic address: xiangyf@shanghaitech.edu.cn.

PMID: 41349522
DOI: 10.1016/j.stem.2025.10.011

Abstract

In this issue of Cell Stem Cell, Wang et al.¹ generate human nucleus basalis of Meynert organoids (hnbMOs), establish a human-specific cholinergic projection system in transplanted assembloids, and identify projection deficits in Down syndrome-derived assembloids. This study provides a valuable model for investigating nbM-related neural circuits and neurological disorders.

MeSH terms

Animals
Brain* / physiology
Humans
Nerve Net*
Organoids / cytology