Optimizing translational efficiency in stem cell clinical research

Yi Hao; Qianwen Chen; Jiayu Yin; Lulu Ding; Xue Pang; Yaojin Peng

doi:10.1016/j.stem.2025.11.002

Optimizing translational efficiency in stem cell clinical research

Cell Stem Cell. 2025 Dec 4;32(12):1802-1806. doi: 10.1016/j.stem.2025.11.002.

Authors

Yi Hao¹, Qianwen Chen², Jiayu Yin³, Lulu Ding³, Xue Pang², Yaojin Peng⁴

Affiliations

¹ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China.
² State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
³ Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China.
⁴ State Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Beijing Institute for Stem Cell and Regenerative Medicine, Beijing 100101, China; University of the Chinese Academy of Sciences, Beijing 100049, China. Electronic address: yaojin.peng@ioz.ac.cn.

PMID: 41349524
DOI: 10.1016/j.stem.2025.11.002

Abstract

Through a comprehensive analysis of stem cell clinical research in China, we reveal robust yet uneven translational linkages between IITs and INDs and propose governance reforms to reduce redundancy, enhance efficiency, and better align exploratory research with regulatory and industrial pathways.

MeSH terms

China
Humans
Stem Cell Research* / legislation & jurisprudence
Translational Research, Biomedical*