Abstract
PIP:
A review was made to understand how plasma binding protein might influence sex-hormone action in target tissues. Steroids are predominately bound to plasma proteins and only unbound steroids enter the cells. Sex-hormone-binding globulin (SHBG) binds to both the main circulating steroid T and E2 but changes in SHBG concentrations exert significant results. Increased SHBG levels increase estrogen production and decreases T activity; whereas, increased androgens increase T action and inhibit SHBG production. These disturbances in hormone maintenance may lead to abnormal adult sex differentiation such as hirsutism and forms of hynaecomastia. By developing SHBG concentration measurement methods-responses of hirsutism to glucocorticoid or estrogem may be assessed. In addition, the effect of thyroid hormones on SHBG may also have therapeutic implications in endocrine disease.
MeSH terms
-
Adolescent
-
Androgen-Insensitivity Syndrome / blood
-
Beta-Globulins / metabolism*
-
Carrier Proteins*
-
Estradiol / blood
-
Estrogens / blood
-
Ethinyl Estradiol / pharmacology
-
Female
-
Glucocorticoids / pharmacology
-
Glycoproteins / blood*
-
Gonadal Steroid Hormones / blood*
-
Gynecomastia / blood
-
Hirsutism / blood
-
Humans
-
Hyperthyroidism / blood
-
Hypogonadism / blood
-
Liver / metabolism
-
Liver Cirrhosis / blood
-
Luteinizing Hormone / blood
-
Male
-
Medroxyprogesterone / pharmacology
-
Molecular Weight
-
Myxedema / blood
-
Ovarian Cysts / blood
-
Pregnancy
-
Protein Binding
-
Puberty
-
Serum Globulins / analysis
-
Serum Globulins / physiology
-
Sex Factors
-
Testosterone / blood
-
Thyroxine / pharmacology
Substances
-
Beta-Globulins
-
Carrier Proteins
-
Estrogens
-
Glucocorticoids
-
Glycoproteins
-
Gonadal Steroid Hormones
-
Serum Globulins
-
Testosterone
-
Ethinyl Estradiol
-
Estradiol
-
Luteinizing Hormone
-
Medroxyprogesterone
-
Thyroxine