Visualization of the Gallbladder on 177 Lu-FAP-2286 SPECT/CT Imaging : A Potential Pitfall

Xinyi Lin; Yang Xie; Wenjuan Li; Tingting Xu; Yue Chen

doi:10.1097/RLU.0000000000006209

Visualization of the Gallbladder on 177 Lu-FAP-2286 SPECT/CT Imaging : A Potential Pitfall

Clin Nucl Med. 2026 Feb 1;51(2):168-170. doi: 10.1097/RLU.0000000000006209. Epub 2025 Nov 18.

Authors

Xinyi Lin^{1

2

3

4}, Yang Xie^{1

2

3

4}, Wenjuan Li^{4

5}, Tingting Xu^{1

2

3

4}, Yue Chen^{1

2

3

4}

Affiliations

¹ Department of Nuclear Medicine, The Affiliated Hospital of Southwest Medical University.
² Nuclear Medicine and Molecular Imaging Key Laboratory of Sichuan Province.
³ Laboratory for Targeted Radiopharmaceuticals Creation.
⁴ Institute of Nuclear Medicine, Southwest Medical University.
⁵ Pediatrics Department of Southwest Medical University Affiliated Hospital, Luzhou, Sichuan, PR China.

PMID: 41359364
DOI: 10.1097/RLU.0000000000006209

Abstract

Fibroblast activation protein (FAP) is a membrane-bound protease predominantly expressed on the surface of cancer-associated fibroblasts activated within the solid tumor microenvironment, while its expression remains minimal in normal tissues. Following radiolabeling, FAP-2286 has demonstrated favorable diagnostic performance and promising therapeutic potential in cancer. The image illustrates the accumulation of 177 Lu-FAP-2286 in the gallbladder, but correlative imaging and knowledge of the radiopharmaceutical helped to avoid a diagnostic pitfall.

Keywords: FAP; FAP-2286; PET/CT; gallbladder.

Publication types

Case Reports

MeSH terms

Endopeptidases
Fibroblast Activation Protein Alpha
Gallbladder* / diagnostic imaging
Gelatinases* / metabolism
Humans
Lutetium*
Membrane Proteins* / metabolism
Radioisotopes
Serine Endopeptidases* / metabolism
Single Photon Emission Computed Tomography Computed Tomography*

Substances

Endopeptidases
Gelatinases
Lutetium
Membrane Proteins
Radioisotopes
Serine Endopeptidases
Fibroblast Activation Protein Alpha
Lutetium-177