Botulinum toxin (BTX) is an effective treatment for improving prosthetic discomfort and reducing limb pain in amputees, particularly those experiencing hyperhidrosis of the residual limb. We describe a technique for administering BTX injections by dividing the residual limb into targeted areas and delivering the treatment in stages. This approach demonstrated an excellent outcome in our patient, enhancing comfort and managing hyperhidrosis. Our case underscores the importance of personalized treatment plans that are tailored to each patient's needs while also addressing factors that may affect their access to effective therapies.