Use of cosmeceuticals such as vitamin E oil with at-home microneedling (MN) devices can lead to local and systemic complications. We report the case of a 44-year-old woman who developed a necrotic ulcer on the chin following self-treatment with vitamin E oil and an at-home MN device. Our case highlights a severe complication associated with an increasingly popular cosmetic practice for facial rejuvenation. It is important for dermatologists to be vigilant in correlating clinical history and recent cosmetic procedures with the histologic findings for timely diagnosis and treatment of unusual lesions on the face.