Saracatinib Promotes Hippocampal Myelin Regeneration and Oligodendrocyte Precursor Cell Maturation by Inhibiting the NOTCH1 Signaling Pathway in Epileptic Mice

Neurochem Res. 2025 Dec 9;51(1):11. doi: 10.1007/s11064-025-04621-6.

Authors

Xinming Luo¹, Wenyue Wu², Baiqi Yu², Sisi Chen², Jing Zhao², Jun Min², Xunhu Gu²

Affiliations

¹ Department of Neurology, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi Province, China. luoxinming99@sina.com.
² Department of Neurology, Second Affiliated Hospital of Nanchang University, No. 1 Minde Road, Nanchang, 330006, Jiangxi Province, China.

PMID: 41364203
DOI: 10.1007/s11064-025-04621-6

No abstract available

Keywords: Epilepsy; NOTCH1; Oligodendrocyte precursor cell; Saracatinib.

Grants and funding

NO. 82260265/The National Natural Science Foundation of China