The history and promise of Treg cells

Christophe Benoist; Dario A A Vignali; Richard A Flavell; Diane Mathis

doi:10.1016/j.immuni.2025.11.011

The history and promise of Treg cells

Immunity. 2025 Dec 9;58(12):2934-2939. doi: 10.1016/j.immuni.2025.11.011.

Authors

Christophe Benoist¹, Dario A A Vignali², Richard A Flavell³, Diane Mathis⁴

Affiliations

¹ Department of Immunology, Harvard Medical School, Boston, MA, USA. Electronic address: cbdm@hms.harvard.edu.
² Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Tumor Microenvironment Center, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA; Cancer Immunology and Immunotherapy Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA.
³ Department of Immunobiology, Yale University, New Haven, CT, USA.
⁴ Department of Immunology, Harvard Medical School, Boston, MA, USA.

PMID: 41371212
DOI: 10.1016/j.immuni.2025.11.011

Abstract

The seminal discoveries that established the role of regulatory T cells in immunological tolerance were recognized by this year's Nobel Prize in Physiology or Medicine. We present here the unfolding of the Treg story, the players involved at various stages, and the explosive growth of knowledge about this fascinating cell population.

Publication types

Historical Article
Review

MeSH terms

Allergy and Immunology* / history
Animals
History, 20th Century
History, 21st Century
Humans
Immune Tolerance* / immunology
Nobel Prize
T-Lymphocytes, Regulatory* / immunology
T-Lymphocytes, Regulatory* / metabolism