Exercise practice and short-QT interval on ECG

J Electrocardiol. 2026 Jan-Feb:94:154173. doi: 10.1016/j.jelectrocard.2025.154173. Epub 2025 Dec 7.

Abstract

A short-QT interval is a potential electrocardiographic finding, while short-QT syndrome (SQTS) is a rare, inherited channelopathy characterized by pathological shortening of the action potential duration leading to an increased risk of life-threatening arrhythmias. In contrast to the long QT syndrome (LQTS), data on the prevalence, diagnosis, risk stratification, treatment and prognosis of short-QT syndrome are scarce. Understanding the true risk of adverse events in exercise population or sporting activities by the patient with short-QT on 12‑leads electrocardiogram is complex: here, we summarize current knowledge and raise questions regarding the challenging relationship between the difficult SQTS diagnosis and exercise practice.

Keywords: Channelopathies; Exercise practice; Short-QT syndrome; Sports; Sudden cardiac death.

Publication types

  • Review

MeSH terms

  • Arrhythmias, Cardiac* / diagnosis
  • Arrhythmias, Cardiac* / physiopathology
  • Electrocardiography* / methods
  • Exercise Test*
  • Exercise* / physiology
  • Humans

Supplementary concepts

  • Short Qt Syndrome