Hook effect for ferritin immunoassays: implications for clinical practice

Clin Chem Lab Med. 2025 Dec 17. doi: 10.1515/cclm-2025-1277. Online ahead of print.

Meshach Asare-Werehene^{1

2

3}, Qiu Yi Shao⁴, Felix Leung⁵, Davor Brinc⁶, Annie Ren⁷, Peter A Kavsak⁸, Daniel R Beriault^{1

4}, Saranya Arnoldo^{1

4}

¹ Department of Laboratory Medicine and Pathobiology, 7938 University of Toronto , Toronto, ON, Canada.
² Lifelabs Medical Laboratory Services, Toronto, ON, Canada.
³ Inflammation and Chronic Disease Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
⁴ Department of Laboratory Medicine, St. Michael's Hospital, Toronto, ON, Canada.
⁵ Department of Pathology and Laboratory Medicine, Sinai Health, Toronto, ON, Canada.
⁶ Division of Clinical Biochemistry, Laboratory Medicine Program, University Health Network, Toronto, ON, Canada.
⁷ Department of Laboratory Medicine and Pathology, William Osler Health System, Toronto, ON, Canada.
⁸ Department of Pathology and Molecular Medicine, McMaster University, Hamilton, ON, Canada.

No abstract available

Keywords: adult-onset still’s disease; ferritin; hook-effect; inflammation; interference.

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