Upper Extremity Muscle Weakness Following Axillary Botox Injection With Sterile Water Reconstitution: A Case Report

Clin Case Rep. 2025 Dec 17;13(12):e71681. doi: 10.1002/ccr3.71681. eCollection 2025 Dec.

Abstract

Severe, unexpected pain during botulinum toxin injection is a critical red flag for reconstitution error. Using sterile water instead of normal saline may cause atypical, wider-spread effects like proximal muscle weakness, even at standard doses. Strict adherence to saline reconstitution is essential to prevent this complication.

Keywords: Botox; axillary; complications; muscle weakness; sterile water.