Operationalizing a research-oriented learning healthcare system across covered entities: cross-institutional strategies and innovations

Npj Health Syst. 2025;2(1):47. doi: 10.1038/s44401-025-00051-2. Epub 2025 Dec 16.

Abstract

The concept of a Learning Health System (LHS) has been widely discussed in academic literature, yet its practical implementation remains a challenge. This paper describes the institutional journey, leadership structure, data governance policies, and technical innovations that together support a scalable and sustainable Research-Oriented LHS. Additionally, we propose an expanded data vision that aligns with interdisciplinary and translational research needs. Supplementary materials provide technical details for those interested in implementing such a model.

Keywords: Business and industry; Health care; Medical research.