Hypnoticlike effects of cannabidiol in the rat

Psychopharmacology (Berl). 1977 Dec 28;55(3):263-5. doi: 10.1007/BF00497858.


The actions of cannabidiol (CBD), one of the cannabis constituents, were assessed on the sleep-wakefulness cycle of male Wistar rats. During acute experiments, single doses of 20 mg/kg CBD decreased slow-wave sleep (SWS) latency. After 40 mg/kg SWS time was significantly increased while wakefulness was decreased. REM sleep was not significantly modified. Following the once-daily injections of 40 mg/kg CBD for a period of 15 days, tolerance developed to all the above-mentioned effects.

MeSH terms

  • Animals
  • Cannabidiol / pharmacology*
  • Cannabinoids / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Tolerance
  • Hypnotics and Sedatives
  • Male
  • Rats
  • Sleep / drug effects*
  • Wakefulness / drug effects*


  • Cannabinoids
  • Hypnotics and Sedatives
  • Cannabidiol