Cryptococcid Sweet Syndrome in the Setting of Hydralazine-Induced ANCA Vasculitis: A Case Report

Abstract

Acute febrile neutrophilic dermatosis, also known as Sweet syndrome, is an inflammatory skin condition characterized by the rapid onset of painful, erythematous plaques or nodules with neutrophilic infiltrate on histology. Rarely, acellular bodies surrounded by vacuolated spaces have been noted within the neutrophilic infiltrate, mimicking Cryptococcus infection. Despite these histological findings, the cryptococcoid variant of Sweet syndrome is not an infectious process. This delineation is essential for the initiation of proper treatment. Here, we present a patient with cryptococcoid Sweet syndrome with concomitant hydralazine-induced ANCA vasculitis, which has seldom been reported in the literature.

Keywords: ANCA; cryptococcoid sweet syndrome; hydralazine; pulmonary and neurological manifestations; vasculitis.