Prescribing clozapine to 10% of patients with schizophrenia may save 320,000 lives and cost 2400 deaths from agranulocytosis

Jose de Leon

doi:10.1016/j.euroneuro.2025.112747

Prescribing clozapine to 10% of patients with schizophrenia may save 320,000 lives and cost 2400 deaths from agranulocytosis

Eur Neuropsychopharmacol. 2026 Mar:104:112747. doi: 10.1016/j.euroneuro.2025.112747. Epub 2025 Dec 23.

Author

Jose de Leon¹

Affiliation

¹ University of Kentucky Mental Health Research Center at Eastern State Hospital, Lexington, KY, USA; Biomedical Research Centre in Mental Health Net (CIBERSAM), Santiago Apóstol Hospital, University of the Basque Country, Vitoria, Spain. Electronic address: jdeleon@uky.edu.

PMID: 41442889
DOI: 10.1016/j.euroneuro.2025.112747

No abstract available

Keywords: Clozapine/adverse effects; Clozapine/therapeutic use; Clozapine/toxicity; Mortality/drug effects; Suicide, Attempted; Suicide, Completed.