A competition model of multilineage priming and cell-fate decisions

Abstract

The transition from a single cell to a body of trillions requires each cell to make fate decisions, committing to one identity among many possible options. This review aims to examine how progenitors and stem cells generate diverse fates through multilineage priming and the competitive interplay of biasing gene-expression programs. Microheterogeneity among progenitors, combined with differential fate biases, gives rise to cell populations with collective multipotency, an emergent state in which the population self-regulates to balance the production of all downstream fates during embryogenesis. We discuss how progenitor cells navigate the epigenetic landscape to control descendant cell-type proportions and how multilineage priming helps reconcile inductive, communication-driven modes of development with autonomous, self-intrinsic fate selection. In parallel, we review computational approaches that leverage single-cell transcriptomics, clonal lineage tracing, and multiomics integration to reconstruct developmental trajectories, identify biases, and dissect the mechanisms of fate selection and commitment.

Keywords: CP: Developmental biology; CP: Stem cell research.