In hypercholesterolemia, adding inclisiran to individually optimized lipid-lowering therapy improved LDL-C levels at 90 d

Ann Intern Med. 2026 Jan;179(1):JC9. doi: 10.7326/ANNALS-25-05115-JC. Epub 2026 Jan 6.

Abstract

GIM/FP/GP: [Formula: see text] Cardiology: [Formula: see text].

MeSH terms

  • Aged
  • Anticholesteremic Agents* / therapeutic use
  • Cholesterol, LDL* / blood
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypercholesterolemia* / blood
  • Hypercholesterolemia* / drug therapy
  • Male
  • Middle Aged
  • RNA, Small Interfering

Substances

  • Cholesterol, LDL
  • Anticholesteremic Agents
  • ALN-PCS
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • RNA, Small Interfering