The correlation between the products of oxidative modification of lipids, proteins, DNA and sleep quality and the presence of the methanogen Methanosphaera stadtmanae in the intestine was assessed in 98 menopausal women. Higher levels of thiobarbituric acid-reactive substances (TBARS) and end-products of protein oxidation were found in the group with sleep disorders (Pittsburgh Sleep Quality Index) in comparison with the control in the sample with M. stadtmanae in the intestine. The presence of this microorganism is associated with a lower level of 8-hydroxy-2'-deoxyguanosine (8-OHdG) in the total sample, as well as in the control group, while for the group with sleep disorders, M. stadtmanae is associated with a higher level of TBARS and Schiff bases. The results indicate possible interaction between M. stadtmanae from the intestine and oxidative processes in the body.
Keywords: Methanosphaera stadtmanae; free radical oxidation; menopause; sleep disorders.
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