Alstonia boonei Promising Source of Anti-inflammatory, Antimalarial, and Ulcer Protective Agents-A Review

Abstract

Alstonia boonei (Apocynaceae) is a medicinal plant widely used in West and Central Africa to manage malaria, fever, intestinal worms, rheumatism, and hypertension. This review compiles evidence on its traditional uses, phytoconstituents, pharmacological activities, and formulations, to encourage future research into its therapeutic potential for modern health challenges. Literature review confirms notable anti-inflammatory, antimalarial, and ulcer-protective activities, while additional studies highlight its potential in antioxidant, anti-diabetic, neuroprotective, antiobesity, cytochrome P450 (CYP) enzyme inhibitory, anti-cataract, anticancer, and antibacterial effects. Phytochemical analysis reveals the presence of diverse bioactive compounds, including alkaloids, saponins, tannins, terpenes, phenolic compounds, and glycosides, which may act individually or synergistically to yield broad pharmacological actions. Recent experimental data reinforce its therapeutic relevance, positioning Alstonia boonei as a promising source of natural products. The wide spectrum of biological activities, coupled with the structural diversity of its phytoconstituents, underscores its importance as a valuable medicinal resource. In conclusion, Alstonia boonei shows significant potential for the development of anti-inflammatory, antimalarial, and ulcerprotective bioactive agents, justifying further scientific exploration and drug discovery efforts.

Keywords: Alstonia boonei; Anti-inflammatory; Antimalarial; Traditional medicine; Triterpenoids; Ulcer-protective..