Two isoforms, two outcomes: How NTRK2 shapes vascular regeneration

Cell Stem Cell. 2026 Jan 8;33(1):7-9. doi: 10.1016/j.stem.2025.12.003.

Abstract

In this issue of Cell Stem Cell, Zhang et al. identify a pathological NTRK2 isoform switch in bronchopulmonary dysplasia that alters the regenerative capacity of capillary endothelial cells, highlighting isoform-specific targeting as a promising strategy for vascular repair.1.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bronchopulmonary Dysplasia* / metabolism
  • Bronchopulmonary Dysplasia* / pathology
  • Endothelial Cells / metabolism
  • Humans
  • Mice
  • Protein Isoforms / metabolism
  • Receptor, trkB* / genetics
  • Receptor, trkB* / metabolism
  • Regeneration*

Substances

  • Protein Isoforms
  • Receptor, trkB