The African Middle East Association of Gastroenterology (AMAGE) clinical practice guidelines for the diagnosis and management of metabolic dysfunction associated fatty liver disease

Ann Hepatol. 2026 Jan-Jun;31(1):102180. doi: 10.1016/j.aohep.2026.102180. Epub 2026 Jan 9.

Abstract

Over the past few decades, the profile of liver diseases in Africa and the Middle East has undergone significant changes. The incidence of metabolic dysfunction-associated fatty liver disease (MAFLD) has risen to alarming levels. Despite the seriousness of the situation, there is a scarcity of local or regional guidelines established to address it. This document presents the clinical practice guidelines from the African Middle East Association of Gastroenterology (AMAGE) related to the screening, diagnosis, and management of MAFLD. It addresses multiple aspects of managing this condition while taking into account local circumstances and the healthcare system's management requirements. These guidelines are intended for routine clinical use, with a specific focus on particular groups when needed.

Keywords: AMAGE; Fatty liver; Guidelines; MAFLD.

Publication types

  • Practice Guideline

MeSH terms

  • Africa / epidemiology
  • Fatty Liver* / diagnosis
  • Fatty Liver* / therapy
  • Gastroenterology* / standards
  • Humans
  • Middle East / epidemiology
  • Non-alcoholic Fatty Liver Disease* / diagnosis
  • Non-alcoholic Fatty Liver Disease* / epidemiology
  • Non-alcoholic Fatty Liver Disease* / therapy
  • Predictive Value of Tests
  • Risk Factors