Introduction: Conjunctival papillomatosis (CP) is a benign epithelial tumor of the conjunctiva that is often associated with human papillomavirus infection. Treatment of CP poses challenges owing to its tendency for local recurrence despite a multitude of treatment options. Although human papillomavirus (HPV) vaccine was originally developed for prevention, it garnered interest for its potential therapeutic role in treating recurrent HPV-associated lesions. A few case reports have described conjunctival papilloma lesion regression after HPV vaccination, offering an alternative treatment option.
Case presentation: We present 3 patients with CP who demonstrated no clinical response to 9-valent HPV vaccination.
Conclusion: These findings highlight some of the limitations of the vaccine in the context of CP.
Keywords: Conjunctival papillomatosis; Gardasil 9; Human papillomavirus subtypes; Human papillomavirus vaccine.
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