Introduction: Periodontitis is an inflammatory disease of the supporting tissues of the teeth, resulting in progressive attachment and bone loss. It is characterized by pocket formation or recession of the gingiva.
Methods: Ten patients suffering from chronic periodontitis, showing evidence of almost identical bilateral intrabony defects, were selected from amongst those reporting to the Department of Periodontology, Punjab Government Dental College and Hospital, Amritsar. The subjects were randomly divided into two groups, that is, Group 1 and Group 2. The defects designated as Group 1 were treated by Hyaluronic acid and bioresorbable membrane after open flap debridement, and Group 2 was treated by placement of bioresorbable membrane alone after open flap debridement.
Results: All treated sites showed remarkable reduction in probing depth, clinical attachment gain, and radiographic bone fill of periodontal defects. The combination of bioresorbable membrane and hyaluronic acid has shown better results in terms of clinical improvements and bone fill than the membrane alone.
Conclusion: It is concluded that the regenerative approach using hyaluronic acid in combination with GTR for the treatment of human intrabony defects resulted in a significant added benefit in terms of CAL gains, PPD reductions, and radiographic defect fill, as well as LBG, compared to the GTR alone.
Keywords: Bioresorbable membrane; bone regeneration; chronic periodontitis; clinical attachment level (CAL); guided tissue regeneration (GTR); hyaluronic acid; intrabony defects; open flap debridement; periodontal therapy; probing pocket depth (PPD).
Copyright: © 2025 Journal of Pharmacy and Bioallied Sciences.