An 81-year-old woman with right lower abdominal pain was referred to our hospital. She was diagnosed as ascending colon cancer with duodenal invasion by CT and colonoscopy. Eight courses of FOLFOX+Bev, 3 courses of 5-FU/LV+Bev and 3 courses of IRI+P-mab were performed, tumor was reduced. Right hemicolectomy and partial duodenectomy were performed. Histopathological findings showed ypTis, N0, M0, ypStage 0, Grade 2. One year after surgery, the patient was alive without recurrence. This result suggests that preoperative chemotherapy may be an option for locally advanced colon cancer with other organ invasion in elderly patients.