The international society of vascular behavioural and cognitive disorders: highlights from VasCog 2025 in the UK

Anna Marseglia; Roxana O Carare; Jessica L Teeling; Saima Hilal; Vera Yuan Cai; Russell Chander; Hugues Chabriat; Deborah Gustafson; Atticus H Hainsworth; Gurpreet Kaur Hansra; Sarah-Naomi James; Audrey Low; Julie Ottoy; Satoshi Saito; Annemieke Ter Telgte; Hilde van den Brink; Frank J Wolters; Prashanthi Vemuri

doi:10.1016/j.cccb.2025.100525

The international society of vascular behavioural and cognitive disorders: highlights from VasCog 2025 in the UK

Cereb Circ Cogn Behav. 2025 Dec 17:10:100525. doi: 10.1016/j.cccb.2025.100525. eCollection 2026.

Authors

Anna Marseglia^{1

2}, Roxana O Carare³, Jessica L Teeling⁴, Saima Hilal⁵, Vera Yuan Cai⁶, Russell Chander⁷, Hugues Chabriat⁸, Deborah Gustafson⁹, Atticus H Hainsworth¹⁰, Gurpreet Kaur Hansra⁷, Sarah-Naomi James¹¹, Audrey Low², Julie Ottoy^{12

13}, Satoshi Saito¹⁴, Annemieke Ter Telgte^{15

16}, Hilde van den Brink¹⁷, Frank J Wolters¹⁸, Prashanthi Vemuri²

Affiliations

¹ Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
² Department of Radiology, Mayo Clinic, Rochester, MN, USA.
³ Clinical Neurosciences, University of Southampton, Southampton, UK.
⁴ Centre for Biological Sciences, Faculty of Natural and Environmental Sciences, University of Southampton, Southampton, UK.
⁵ Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
⁶ Department of Medicine and Therapeutics, Faculty of Medicine, Division of Neurology, Gerald Choa Neuroscience Institute, Lau Tat-chuen Research Centre of Brain Degenerative Diseases in Chinese, Therese Pei Fong Chow Research Centre for Prevention of Dementia, Lui Che Woo Institute of Innovative Medicine, Li Ka Shing Institute of Health Science, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong SAR, China.
⁷ Centre for Healthy Brain Ageing (CHeBA), School of Clinical Medicine, Discipline of Psychiatry & Mental Health, Faculty of Medicine and Health, University of New South Wales, Sydney, Australia.
⁸ University Hospital LARIBOISIERE, France.
⁹ Department of Neurology, State University of New York Downstate Health Sciences University, Brooklyn NY, USA.
¹⁰ St George's University of London, UK.
¹¹ Unit of Lifelong Health and Ageing, University College London, London, UK.
¹² Sunnybrook Research Institute, University of Toronto, Toronto, Canada.
¹³ Department of Medicine (Neurology), Faculty of Medicine, University of Toronto, Toronto, Canada.
¹⁴ Department of Neurology, National Cerebral and Cardiovascular Center, Suita, Japan.
¹⁵ VASCage - Centre on Clinical Stroke Research, Innsbruck, Austria.
¹⁶ Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria.
¹⁷ J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
¹⁸ Departments of Epidemiology and Radiology & Nuclear Medicine, Erasmus MC - University Medical Center Rotterdam, the Netherlands.

Abstract

•AI-driven tools and multimodal biomarkers emerged as key for early VCID detection.•Novel neuroimaging, fluid, and retinal markers show promise for precision diagnostics.•BBB leakage and inflammation could early drive small vessel disease and VCID.•Clinical trials explore drug repurposing and hybrid lifestyle-pharmacological interventions.•Genetic insights into CADASIL reveal shared pathways with sporadic SVD.

Keywords: Early career investigators; Epidemiology; Fluid, Retinal, Cardiac biomarkers; Hereditary SVD; Neuroimaging; Pathophysiology; Small vessel disease; Treatment; Vascular cognitive impairment and dementia.

Publication types

Letter