Formulation of a trace element solution for long-term parenteral nutrition

Am J Hosp Pharm. 1978 Feb;35(2):165-8.

Abstract

The reproduction of phage T7 in the presence of hydroxylamine (HA) (mutagenesis in vivo) results in the phenotypic suppression of some amber mutants. The presence of O-methylhydroxylamine (OMHA) results in a similar effect, including a simlilar mechanism for the action of the two compounds. Since the rate of reaction of mutagen with nucleoside residues under these conditions is negligibly low, one of the most plausible explanations of this effect is the enzymic formation of modified precursors and their incorporation into bacterial tRNAs or phage-induced RNA.

MeSH terms

  • Chemistry, Pharmaceutical
  • Drug Compounding
  • Humans
  • Parenteral Nutrition*
  • Solutions
  • Trace Elements / administration & dosage*

Substances

  • Solutions
  • Trace Elements