A Ciliary Phosphoinositide Pathway Regulates the Dosage of Polycystins in Primary Cilia

J Am Soc Nephrol. 2025 Nov 25. doi: 10.1681/ASN.0000000942. Online ahead of print.

Authors

Chuan Chen^{1

2}, Zhifei Wang³, Yue Gao^{1

2}, Madilyn R Ellis¹, Biyun Ji^{1

2}, Cynthia J Sieben², Courtney J Haycraft⁴, Mandy Croyle⁴, Ariana Aghevli¹, Qingwen Xu¹, Jielu H Robichaud^{1

2}, Kai He^{1

2}, Chunhua Chen¹, Yan Huang^{1

2}, Bradley K Yoder⁴, Jinghua Hu^{1

2}, Peter C Harris^{1

2}, Yong Yu³, Kun Ling^{1

2}

Affiliations

¹ Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota.
² Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota.
³ Department of Biological Sciences, St. John's University, New York, New York.
⁴ Department of Cell, Developmental and Integrative Biology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama.

PMID: 41563398
DOI: 10.1681/ASN.0000000942

No abstract available

Keywords: ADPKD; cell biology and structure; cystic kidney disease; polycystic kidney disease.

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