Glycogen Storage Disease in Twins: When Two Lives Reflect One Silent Battle

Clin Case Rep. 2026 Jan 20;14(1):e71889. doi: 10.1002/ccr3.71889. eCollection 2026 Jan.

Abstract

Early recognition of hepatomegaly, hypoglycemia, and elevated liver enzymes in infants is crucial for diagnosing glycogen storage disease. Liver biopsy with PAS-diastase staining provides definitive confirmation. Prompt metabolic management and regular follow-up are essential to prevent progression of fibrosis and long-term hepatic complications.

Keywords: glycogen; glycogen storage disease; liver; metabolic disorder; neonatology.