Multi-target actions of natural flavonoids in skin flap survival: Opportunities and challenges

Yan-Yan Chen; Yi-Fei Yang; Yu-Yun Xiong; Hui Sun; Yu-Mei Li

doi:10.1016/j.burns.2026.107870

Multi-target actions of natural flavonoids in skin flap survival: Opportunities and challenges

Burns. 2026 Mar;52(2):107870. doi: 10.1016/j.burns.2026.107870. Epub 2026 Jan 18.

Authors

Yan-Yan Chen¹, Yi-Fei Yang¹, Yu-Yun Xiong¹, Hui Sun², Yu-Mei Li³

Affiliations

¹ Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China; Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China.
² Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China; Department of Dermatology, Huzhou Central Hospital, Fifth School of Clinical Medicine of Zhejiang Chinese Medical University, Huzhou, Zhejiang 313003, China. Electronic address: 20256037@zcmu.edu.cn.
³ Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China; Department of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China. Electronic address: yumeili@ujs.edu.cn.

PMID: 41579449
DOI: 10.1016/j.burns.2026.107870

No abstract available

Keywords: Flavonoids; JAK–STAT signaling; Microenvironments; NF-κB / NLRP3 inflammasome; Preclinical models; Skin flap survival; Translational limitations.

Publication types

Letter