Association of Anatomical Location with Outcomes after Microwave Ablation Treatment of Parathyroid Adenomas

Abstract

Purpose: To investigate the effect of parathyroid adenoma location on treatment success and adverse events.

Materials and methods: A retrospective, observational case study included 285 patients with parathyroid adenomas treated at a single center. Preprocedural and postprocedural blood parameters, ultrasound (US) findings, and parathyroid adenoma locations (Perrier classification) were investigated in relation to procedural success and adverse events. Procedural success was defined as the patient's calcium and parathyroid hormone levels remaining within normal limits for at least 6 months of follow-up and the gradual reduction in size and absence of blood flow in the parathyroid adenoma on control Doppler US.

Results: Overall procedural success was 88.4%, and the risk of transient hoarseness was 3.8% in all groups. In the Perrier Type D group, located near the recurrent laryngeal nerve, the procedure success rate was lowest at 72.2%. However, no significant differences were found between location groups in terms of the risk of transient hoarseness or procedure success.

Conclusions: Microwave ablation therapy of patathyroid adenomas has a high success rate across all locations and a low risk of adverse events. In Perrier Type D adenomas, the success rate was lower; however, this difference did not reach statistical significance.