Prediction of medication overuse in patients with migraine using cox regression and machine learning: a real-world cohort

Teerapong Aramruang; Pawin Numthavaj; Panu Looareesuwan; Thunyarat Anothaisintawee; Patratorn Kunakorntham; Oraluck Pattanaprateep; Charungthai Dejthevaporn; Ammarin Thakkinstian

doi:10.1186/s10194-026-02269-3

Prediction of medication overuse in patients with migraine using cox regression and machine learning: a real-world cohort

J Headache Pain. 2026 Jan 24. doi: 10.1186/s10194-026-02269-3. Online ahead of print.

Authors

Teerapong Aramruang^{1

2}, Pawin Numthavaj³, Panu Looareesuwan¹, Thunyarat Anothaisintawee¹, Patratorn Kunakorntham⁴, Oraluck Pattanaprateep¹, Charungthai Dejthevaporn⁵, Ammarin Thakkinstian¹

Affiliations

¹ Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 RAMA VI Road, Rachathevi, Bangkok, 10400, Thailand.
² Department of Pharmacy, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
³ Department of Clinical Epidemiology and Biostatistics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, 270 RAMA VI Road, Rachathevi, Bangkok, 10400, Thailand. pawin.num@mahidol.ac.th.
⁴ Department of Information Technology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
⁵ Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

PMID: 41580605
DOI: 10.1186/s10194-026-02269-3

No abstract available

Keywords: Cox regression; Electronic health records; Machine learning; Medication overuse; Medication overuse headache; Migraine; Prediction model; Real-world data; Survival analysis.