Surgical Treatment of Primary Localized Cutaneous Nodular Amyloidosis of the Nose: Resection and Reconstruction With a Nasolabial Flap

Daisuke Hirao; Tomoki Himejima; Michika Fukui; Masakatsu Hihara; Natsuko Kakudo

doi:10.7759/cureus.99878

Surgical Treatment of Primary Localized Cutaneous Nodular Amyloidosis of the Nose: Resection and Reconstruction With a Nasolabial Flap

Cureus. 2025 Dec 22;17(12):e99878. doi: 10.7759/cureus.99878. eCollection 2025 Dec.

Authors

Daisuke Hirao¹, Tomoki Himejima², Michika Fukui¹, Masakatsu Hihara¹, Natsuko Kakudo¹

Affiliations

¹ Department of Plastic and Reconstructive Surgery, Kansai Medical University, Hirakata, JPN.
² Department of Plastic and Reconstructive Surgery, Yao Municipal Hospital, Yao, JPN.

Abstract

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare form of amyloidosis limited to the skin. A 39-year-old woman had noticed a tumor on her right nasal ala for five years. She presented it to our hospital after developing a similar lesion on her right cheek. Histopathological examination following surgical excision revealed AL amyloidosis (κ-light chain type), ruling out systemic amyloidosis and confirming the diagnosis of PLCNA. The nasal lesion was excised and reconstructed with a nasolabial flap, resulting in excellent aesthetic and functional outcomes. No recurrence has been observed during a 21-month follow-up. PLCNA in young adults is rare, and long-term follow-up is crucial due to the potential for systemic progression. This case highlights the importance of accurate diagnosis and the benefits of local flap reconstruction in cosmetically sensitive areas.

Keywords: amyloidosis; cutaneous; nasolabial flap; nose; plcna.

Publication types

Case Reports