Pirtobrutinib in relapsed or refractory mantle cell lymphoma: outcomes from the compassionate use program in Italy

Daniela Estefania Banegas; Isacco Ferrarini; Andrea Bernardelli; Alessia Moioli; Vittorio Ruggero Zilioli; Luca Nassi; Chiara Rusconi; Beatrice Casadei; Cinzia Pellegrini; Guido Gini; Giuseppe Gritti; Giulia Daghia; Elsa Pennese; Luigi Petrucci; Simone Ferrero; Sonya De Lorenzo; Sara Veronica Usai; Ausilia Gorgone; Massimo Gentile; Alessia Castellino; Anna Vanazzi; Luigi Curreli; Lucia Morello; Monica Tani; Daniela Renzi; Brunella Mola; Alberto Fabbri; Alfredo Molteni; Roberta Sciarra; Pier Luigi Zinzani; Carlo Visco

doi:10.1080/10428194.2026.2621825

Pirtobrutinib in relapsed or refractory mantle cell lymphoma: outcomes from the compassionate use program in Italy

Leuk Lymphoma. 2026 Jan 29:1-5. doi: 10.1080/10428194.2026.2621825. Online ahead of print.

Authors

Daniela Estefania Banegas¹, Isacco Ferrarini¹, Andrea Bernardelli¹, Alessia Moioli¹, Vittorio Ruggero Zilioli², Luca Nassi³, Chiara Rusconi⁴, Beatrice Casadei⁵, Cinzia Pellegrini^{5

6}, Guido Gini⁷, Giuseppe Gritti⁸, Giulia Daghia⁹, Elsa Pennese¹⁰, Luigi Petrucci¹¹, Simone Ferrero¹², Sonya De Lorenzo¹³, Sara Veronica Usai¹⁴, Ausilia Gorgone¹⁵, Massimo Gentile^{16

17}, Alessia Castellino¹⁸, Anna Vanazzi¹⁹, Luigi Curreli²⁰, Lucia Morello²¹, Monica Tani²², Daniela Renzi²³, Brunella Mola²⁴, Alberto Fabbri²⁵, Alfredo Molteni²⁶, Roberta Sciarra²⁷, Pier Luigi Zinzani^{5

6}, Carlo Visco¹

Affiliations

¹ Hematology Unit, Section of Biomedicine of Innovation, Department of Engineering for Innovative Medicine, Verona University, Verona, Italy.
² Division of Hematology, ASST Grande Ospedale Metropolitano Niguarda, Milan, Italy.
³ Department of Hematology, Careggi Hospital and University of Florence, Florence, Italy.
⁴ Hematology and Bone Marrow Transplantation, IRCSS Istituto Nazionale Tumori, Milan, Italy.
⁵ IRCCS Azienda Ospedaliero, Universitaria di Bologna Istituto di Ematologia 'Seràgnoli', Bologna, Italy.
⁶ Dipartimento di Scienze Mediche e Chirurgiche, Università di Bologna, Bologna, Italy.
⁷ Clinic of hematology AOU delle Marche, Marche Polytechnic University, Ancona, Italy.
⁸ Hematology, ASST Papa Giovanni XXIII, Bergamo, Italy.
⁹ Hematology, Dipartimento di Scienze Mediche, Azienda Ospedaliero-Universitaria di Ferrara. Arcispedale S.Anna, Ferrara, Italy.
¹⁰ UOC Ematologia Clinica, Dipartimento Oncologico-Ematologico, Presidio Ospedaliero Santo Spirito, Pescara, Italy.
¹¹ Department of Translational and Precision Medicine, Sapienza University, Rome, Italy.
¹² Hematology Division I, Department of Molecular Biotechnologies and Health Sciences, University of Turin/University Hospital A.O.U. 'Città della Salute e della Scienza', Turin, Italy.
¹³ Hematology, Azienda Ospedaliera San Giuseppe Moscati, Avellino, Italy.
¹⁴ Division of Hematology, Ospedale Oncologico Armando Businco, Cagliari, Italy.
¹⁵ Hematology, ARNAS Garibaldi, Catania, Italy.
¹⁶ Haematology Unit, Department of Onco-Haematology, AO of Cosenza, Cosenza, Italy.
¹⁷ Department of Pharmacy, Health and Nutritional Science, University of Calabria, Rende, Italy.
¹⁸ Hematology, Azienda Ospedaliera Santa Croce e Carle, Cuneo, Italy.
¹⁹ Oncohematology Division, European Institute of Oncology IRCCS, Milan, Italy.
²⁰ Hematology, SC Oncologia- Ematologia Ospedale San Martino Oristano, Oristano, Italy.
²¹ Hematology Unit, Ospedale Guglielmo da Saliceto, Piacenza, Italy.
²² Hematology, Ospedale 'Santa Maria delle Croci' di Ravenna, Ravenna, Italy.
²³ Hematology, IRCCS Istituto Nazionale Tumori Regina Elena, Roma, Italy.
²⁴ Hematology, Azienda Ospedaliero Universitaria di Sassari, Sassari, Italy.
²⁵ Division of Hematology, Azienda Ospedaliera Universitaria Senese & University of Siena, Siena, Italy.
²⁶ Hematology, ASST Cremona, Cremona, Italy.
²⁷ Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

PMID: 41608968
DOI: 10.1080/10428194.2026.2621825

No abstract available