Improved Dye-Filling Protocol for Multiple Nematode Species

MicroPubl Biol. 2026 Jan 14:2026:10.17912/micropub.biology.001963. doi: 10.17912/micropub.biology.001963. eCollection 2026.

Abstract

Dye-filling has been used extensively to study the development and morphology of sensory neurons in the nematode C. elegans . Here, we report a modified dye-filling protocol that improves the robustness of amphid, phasmid, and inner labial neuron dye-filling in C. elegans , as well as in the nematode satellite model P. pacificus. Our method also allows for the consistent visualization of male specific ray sensory neurons and associated support cells in these species.