Not Just Depression: A Delayed Diagnosis of HIV Dementia in an Adolescent Boy

Pediatrics. 2026 Mar 1;157(3):e2025071517. doi: 10.1542/peds.2025-071517.

Abstract

Here, we present a unique case of a 17-year-old boy who presented with progressive lower extremity weakness, functional decline, and mood changes and was ultimately found to have a new diagnosis of AIDS from perinatally acquired HIV infection. This case demonstrates the discovery of a delayed diagnosis of HIV with important lessons for all pediatricians. It highlights the need for pediatricians to maintain a high index of suspicion and consider broad differentials and appropriate workup for at-risk youth with known psychiatric conditions. It is essential to identify at-risk youth early to prevent progression and severity of illness.

Publication types

  • Case Reports

MeSH terms

  • AIDS Dementia Complex* / diagnosis
  • AIDS Dementia Complex* / psychology
  • Adolescent
  • Delayed Diagnosis*
  • Depression* / diagnosis
  • HIV Infections / diagnosis
  • Humans
  • Male