Clinical characteristics and outcomes of appendiceal neoplasms in inflammatory bowel disease: A tertiary care center experience

Clin Res Hepatol Gastroenterol. 2026 Mar;50(3):102778. doi: 10.1016/j.clinre.2026.102778. Epub 2026 Feb 1.

Abstract

Background and aims: A direct causal association between inflammatory bowel disease (IBD) and appendiceal neoplasm (AN) is unclear.

Methods: Patients with IBD and AN were identified from 1992 to 2023 using bioinformatics and natural language processing tools.

Results: Thirty-one patients were identified. The most common type of AN was appendiceal mucinous neoplasm (83.9 %). Three patients with ulcerative colitis (9.7 %) had recurrence after surgical resection due to peritoneal seeding.

Conclusions: Incidence and recurrence of AN in patients with IBD is low. Further studies to compare AN in patients with and without IBD are needed to determine if IBD predisposes to development of this complication.

Keywords: Appendix neoplasm; Inflammatory bowel disease; Malignancy.

MeSH terms

  • Adenocarcinoma, Mucinous* / surgery
  • Adult
  • Aged
  • Appendiceal Neoplasms* / complications
  • Appendiceal Neoplasms* / diagnosis
  • Appendiceal Neoplasms* / epidemiology
  • Appendiceal Neoplasms* / etiology
  • Appendiceal Neoplasms* / surgery
  • Colitis, Ulcerative / complications
  • Female
  • Humans
  • Inflammatory Bowel Diseases* / complications
  • Male
  • Middle Aged
  • Retrospective Studies
  • Tertiary Care Centers
  • Young Adult