Juvenile type of generalized ceroid-lipofuscinosis (Spielmeyer-Sjögren syndrome) I. Clinical findings

Neuropadiatrie. 1978 Feb;9(1):3-27. doi: 10.1055/s-0028-1085407.

Abstract

Thirteen patients with the clinical course of the juvenile type of generalized ceroid-lipofuscinosis were examined clinically, ophthalmologically, neurologically and psychiatrically. This included registration of EEG, x-ray, brain scintigraphy, motor nerve conduction velocity, ERG, fundus photography and bioptical investigations including electron microscopy. The children suffered from progressing decrease of visual acuity, decline of mental capacities, and later on speech and gait disturbances. The most characteristic findings are presented in case reports, two tables and fourteen pictures.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Basal Ganglia Diseases / etiology
  • Cerebellar Ataxia / etiology
  • Ceroid / analysis*
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Lipofuscin / analysis*
  • Lymphocytes / pathology
  • Male
  • Neurons / analysis
  • Pigments, Biological / analysis*
  • Sphingolipidoses / complications
  • Sphingolipidoses / diagnosis*
  • Vacuoles

Substances

  • Ceroid
  • Lipofuscin
  • Pigments, Biological