Evidence gaps in the effects of exercise on SASP-Related biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials

Eleuterio A Sánchez-Romero; Oliver Martínez-Pozas; Samuel Fernández-Carnero; Álvaro Romero-Rosado; Rob Sillevis; Juan Nicolás Cuenca-Zaldívar

doi:10.1186/s12877-026-07025-5

Evidence gaps in the effects of exercise on SASP-Related biomarkers in older adults: a systematic review and meta-analysis of randomized controlled trials

BMC Geriatr. 2026 Feb 6. doi: 10.1186/s12877-026-07025-5. Online ahead of print.

Authors

Eleuterio A Sánchez-Romero^{1

2

3

4}, Oliver Martínez-Pozas^{5

6}, Samuel Fernández-Carnero^{7

8}, Álvaro Romero-Rosado^{9

10}, Rob Sillevis¹¹, Juan Nicolás Cuenca-Zaldívar^{12

9

13}

Affiliations

¹ Research Group in Nursing and Health Care, Puerta de Hierro Health Research Institute-Segovia de Arana (IDIPHISA), Majadahonda, 28222, Spain. esanchezromero@fgcu.edu.
² Department of Rehabilitation Sciences, Florida Gulf Coast University, Fort Myers, FL, 33965, USA. esanchezromero@fgcu.edu.
³ Interdisciplinary Research Group on Musculoskeletal Disorders, Madrid, 28014, Spain. esanchezromero@fgcu.edu.
⁴ Physiotherapy and Orofacial Pain Working Group, Sociedad Española de Disfunción Craneomandibular y Dolor Orofacial (SEDCYDO), Madrid, 28009, Spain. esanchezromero@fgcu.edu.
⁵ Interdisciplinary Research Group on Musculoskeletal Disorders, Madrid, 28014, Spain. oliver.martp@gmail.com.
⁶ Physiotherapy and Orofacial Pain Working Group, Sociedad Española de Disfunción Craneomandibular y Dolor Orofacial (SEDCYDO), Madrid, 28009, Spain. oliver.martp@gmail.com.
⁷ Interdisciplinary Research Group on Musculoskeletal Disorders, Madrid, 28014, Spain. samuel.fernandezc@uah.es.
⁸ Departamento de Fisioterapia, Universidad de Alcalá, Facultad de Enfermería y Fisioterapia, Alcalá de Henares, 28801, Spain. samuel.fernandezc@uah.es.
⁹ Interdisciplinary Research Group on Musculoskeletal Disorders, Madrid, 28014, Spain.
¹⁰ Departamento de Fisioterapia, Universidad de Alcalá, Facultad de Enfermería y Fisioterapia, Alcalá de Henares, 28801, Spain.
¹¹ Department of Rehabilitation Sciences, Florida Gulf Coast University, Fort Myers, FL, 33965, USA.
¹² Research Group in Nursing and Health Care, Puerta de Hierro Health Research Institute-Segovia de Arana (IDIPHISA), Majadahonda, 28222, Spain.
¹³ Physical Therapy Unit, Primary Health Care Center "El Abajón", Las Rozas de Madrid, 28231, Spain.

PMID: 41652340
DOI: 10.1186/s12877-026-07025-5

No abstract available

Keywords: Aging; Cellular senescence; Inflammaging; Inflammatory biomarkers; Physical exercise; Senescence markers; Senescence-Associated secretory phenotype (SASP); p16^INK4a^; p21.

Publication types

Systematic Review